Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

An Alpha-globulin Allotype in the Mouse (MuB1)

Nature volume 200, page 781 (1963)Cite this article

Abstract

POLYMORPHISM, detected by antibody from individuals of the same species (allotypy), has so far been observed only in the γ- (ref. 1) and β-globulins (ref. 2). In man, a class of α-globulin Gc1 and Gc2 is subject to genetic variations and has been revealed by antibodies of heterologous origin3. Polymorphism of other α-globulins, the haptoglobins in several mammalian1 species and recently the trypsin inhibitors in man4,5 have been detected by other means. So far, the polymorphism of serum proteins has been most thoroughly examined in man and rabbit. In the mouse the genetic variation of the transferrins6 and of an allelic pair of γ-globulins (MuA1 and MuA2) (refs. 7–10) have been examined. We wish to report here a new allotypic specificity among the γ-globulins of the mouse.

Access through your institution
Buy or subscribe

This is a preview of subscription content, access via your institution

Access options

Access through your institution

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Cinader, B., and Dubiski, S., in Colloq. Intern. Centre Nat. Rech. Sci., Paris, edit. by Bussard, A., 116, 255 (1963).

    Google Scholar 

  2. Blumberg, B. S., Ann. N.Y. Acad. Sci., 103, 1052 (1963).

    Article  ADS  CAS  Google Scholar 

  3. Hirschfeld, J., Sci. Tools, 8, 17 (1961).

    CAS  Google Scholar 

  4. Allison, A. C., Proc. Biochem. Soc., April 1963 (Biochem. J., in the press).

  5. Landerman, N. S., Webster, M. E., Becker, E. L., and Ratcliffe, H. E., J. Allergy, 33, 330 (1963).

    Article  Google Scholar 

  6. Cohen, B. L., and Schreffler, D. C., Genet. Res., 2, 306 (1961).

    Article  Google Scholar 

  7. Kelus, A., and Moor-Jankowski, J. K., Nature, 191, 1405 (1961).

    Article  ADS  CAS  Google Scholar 

  8. Dubiski, S., and Cinader, B., Nature, 197, 705 (1963).

    Article  ADS  CAS  Google Scholar 

  9. Dubiski, S., and Cinader, B., Canad. J. Biochem. Physiol., 41, 1311 (1963).

    Article  Google Scholar 

  10. Wunderlich, J., and Herzenberg, L. A., Proc. U.S. Nat. Acad. Sci., Wash., 49, 592 (1963).

    Article  ADS  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Subdivision of Immunochemistry, Division of Biological Research, Ontario Cancer Institute,

    B. CINADER & S. DUBISKI

  2. Departments of Medical Biophysics and Pathological Chemistry, University of Toronto,

    B. CINADER & S. DUBISKI

Authors
  1. B. CINADER
    View author publications

    Search author on:PubMed Google Scholar

  2. S. DUBISKI
    View author publications

    Search author on:PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

CINADER, B., DUBISKI, S. An Alpha-globulin Allotype in the Mouse (MuB1). Nature 200, 781 (1963). https://doi.org/10.1038/200781a0

Download citation

  • Issue date:

  • DOI: https://doi.org/10.1038/200781a0

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing