Abstract
THE theory of genetic recombination by the formation of hybrid DNA1 postulates that a recombinational event involves breakage of single DNA nucleotide chains (primary breaks), and rejoining by base pairing between homologous chains. Thus the DNA molecules are hybrid in the region of the break, and, when these hybrid molecules include sites of heterozygosity, a correction process as suggested by Holliday2, could operate to restore the homozygosity of the molecule. This could cause non-reciprocal recombination if the correction were in the same direction on both strands involved. If a strand remains unconnected, the marker involved segregates at the first post-meiotic division.
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References
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HASTINGS, P., WHITEHOUSE, H. A Polaron Model of Genetic Recombination by the Formation of Hybrid Deoxyribonucleic Acid. Nature 201, 1052–1054 (1964). https://doi.org/10.1038/2011052b0
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DOI: https://doi.org/10.1038/2011052b0
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