Abstract
IT has been shown1–3 that atractyloside, like oligomycin4, acts as inhibitor of oxidative phosphorylation by a specific interference with energy-transfer reactions. The competition between atractyloside and ADP on oxygen and phosphate uptake by mitochondria3 would seem to indicate that the effect of atractyloside is due to inhibition of the ADP utilizing process in the coupling system.
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BRUNI, A., LUCIANI, S. & CONTESSA, A. Inhibition by Atractyloside of the Binding of Adenine-nucleotides to Rat-liver Mitochondria. Nature 201, 1219–1220 (1964). https://doi.org/10.1038/2011219a0
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DOI: https://doi.org/10.1038/2011219a0
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