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Relation of Renal Glutamine Transam inase-ω-Amidase Activity to Ammonia Excretion in the Rat

Nature volume 201, pages 1229–1230 (1964)Cite this article

Abstract

INVESTIGATIONS of the relation of renal glutaminase activity to ammonia excretion during metabolic acidosis1,2 and potassium deficiency3 indicate that glutaminase is involved in the regulation of urinary ammonia production in the rat. The increase in renal glutamine transaminase-ω-amidase (GTA) activity following administration of ammonium chloride to rats for 2–3 weeks4 suggests that this enzyme system, which catalyses the transamination-deamination of glutamine5, might also play a part in the regulation of urinary ammonia production. Evidence is given here which supports this hypothesis.

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Author notes

  1. LEON GOLDSTEIN: Research Career Development awardee of the National Institutes of Health.

Authors and Affiliations

  1. Department of Physiology, Harvard Medical School, Boston, Mass.

    LEON GOLDSTEIN

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  1. LEON GOLDSTEIN
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GOLDSTEIN, L. Relation of Renal Glutamine Transam inase-ω-Amidase Activity to Ammonia Excretion in the Rat. Nature 201, 1229–1230 (1964). https://doi.org/10.1038/2011229a0

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