Abstract
THE injection of preparations of spinal cord into certain animals has been shown to cause the development of an allergic encephalomyelitis1,2. We have been examining the effects of the addition of serum from guinea pigs suffering from experimental allergic encephalomyelitis (EAE) serum on the metabolic activity of slices of rat brain tissue, as measured by in vitro techniques. Other workers have shown that serum from affected animals can cause tissue breakdown in tissue cultures3,4, and the results of our experiments, in which we measure net free fatty acid output of brain slices incubated in a balanced medium are consistent with the hypothesis that EAE serum causes a degenerative change.
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Rivers, T. M., and Schwenkter, F. F., J. Exp. Med., 61, 689 (1935).
Freund, J., Stern, E. R., and Pisani, T. M., J. Immunol., 57, 179 (1947).
Bornstein, M. B., and Appel, S. H., J. Neuropath. Exp. Neurol., 20, 141 (1961).
Pette, E., and Pette, E., J. Neuropath. Exp. Neurol., 22, 528 (1963).
Wardlaw, A., and Moloney, P., Canad. J. Biochem. Physiol., 39, 695 (1961).
Dole, V. P., J. Clin. Invest., 35, 150 (1956).
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CLARKE, D., GEIGER, L. Effect of Experimental Allergic Encephalomyelitis Serum on Fatty Acid Output of Brain Slices. Nature 201, 401 (1964). https://doi.org/10.1038/201401a0
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DOI: https://doi.org/10.1038/201401a0
