Abstract
PROGESTERONE (pregn-4-ene-3,20-dione), corticosterone (11β,21-dihydroxypregn-4-ene-3,20-dione) and deoxycorticosterone (21-hydroxypregn-4-ene-3,20-dione) have been shown to be precursors of aldosterone1–5. Aldosterone (11β,21-dihydroxypregn-4-ene-3,20-dione-18-al) is produced in the glomerulosa zona of the adrenal cortex6–8. It could be assumed that the biogenesis of aldosterone was preceded by hydroxylation of corticosterone in C18. Nicolis and Ulick9 obtained a slight yield of aldosterone (0.2 per cent) by incubation of tritiated-18-hydroxy-corticosterone (11β,18,21-trihydroxypregn-4-ene-3,20-dione) with bull-frog adrenal tissue and beef zona glomerulosa tissue. Stachenko and Giroud10 considered that the cyclic 18→20 hemiketal form of 18-hydroxy-corticosterone11 was responsible for this lack of conversion of 18-hydroxy-corticosterone to aldosterone.
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PASQUALINI, J. Conversion of Tritiated-18-hydroxy-corticosterone to Aldosterone by Slices of Human Cortico-adrenal Gland and Adrenal Tumour. Nature 201, 501 (1964). https://doi.org/10.1038/201501a0
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DOI: https://doi.org/10.1038/201501a0
