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Abnormal Serum Components after Escherichia coli Endotoxin Administration to Male and Female Rats

Abstract

PREVIOUS investigations1,2 have established that intra-peritoneal injection of cadmium chloride into rats was followed 24 h later by the appearance in the serum of an abnormal component, identified as a distinct band on starch-gel electrophoresis and designated A.S.C. This component reached a maximum concentration in the serum at 48 h following a single dose and gradually decreased over the subsequent 7 days. Other metallic salts at a similar dose rate were tested in an identical manner. At a level of 1 mg/kg, the following sequence of effectiveness was observed: mercury > beryllium, cadmium, copper > manganese > chromium, nickel > iron, cobalt. Lead had no effect.

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LAWFORD, D., WHITE, B. Abnormal Serum Components after Escherichia coli Endotoxin Administration to Male and Female Rats. Nature 201, 705–706 (1964). https://doi.org/10.1038/201705a0

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