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Acetyl-carnitine in Heart and Liver

Nature volume 202, page 91 (1964)Cite this article

Abstract

Friedman and Fraenkel1 showed that the reversible acetylation of L-carnitine by acetyl-coenzyme A could be catalysed by extracts from pigeon liver. Carnitine acetyl transferase (E.C.2.3.1.7) has recently been partly purified from pig heart2. The existence of a carnitine palmitoyl transferase, distinct from the acetyl transferase, has been shown3,5, and it has been suggested4,5 that acyl-carnitine compounds might play a part in the transfer of activated acyl-groups across the mitochondrial membrane. Intracellular levels of acyl-carnitinecompounds might be expected to be influenced by conditions known to affect the tissue levels of acyl-coenzyme A compounds6,7.

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References

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Authors and Affiliations

  1. Department of Biochemistry, University of Cambridge,

    D. J. PEARSON & P. K. TUBBS

Authors
  1. D. J. PEARSON
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  2. P. K. TUBBS
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PEARSON, D., TUBBS, P. Acetyl-carnitine in Heart and Liver. Nature 202, 91 (1964). https://doi.org/10.1038/202091a0

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