Abstract
THE hypothesis that there is a correlation between the pathogenesis of atheroma and the metabolism of lipids appears to have sprung from the fact that the earliest lesion which the pathologist sees in atheroma is the accumulation of lipid material in the intima and sub-intimal connective tissues. Among the various substances classed as lipids that may play a part in causing atheroma, cholesterol and its esters are the most highly favoured suspects. This suspicion has been harboured since Vogel1 established in 1847 the invariable presence of cholesterol in atheromatous lesions, and this idea was much strengthened by the production of experimental atheroma in rabbits by giving them pure cholesterol in oil2,3.
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References
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McKINNEY, B., LUCK, C. Serum Lipids in some purely Herbivorous Wild Animals. Nature 202, 705–706 (1964). https://doi.org/10.1038/202705b0
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DOI: https://doi.org/10.1038/202705b0
