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Thymus and X-radiation in the Termination of Acquired Immunological Tolerance in the Adult Mouse

Nature volume 202, pages 712–713 (1964)Cite this article

Abstract

ACQUIKED immunological tolerance wanes gradually with time after antigen injections are stopped1. In some experiments the termination of the tolerant state has been hastened by whole-body X-radiation2–5. Weigle has recently found that tolerance to bovine serum albumin (BSA) induced by giving very large quantities of antigen to new-born rabbits is not terminated by whole-body X-radiation, nor by passive anti-BSA nor by both these agents together6. Weigle has also reported that termination of tolerance to BSA in rabbits following the injection of a serologically related antigen is not thymus dependent7. We have recently reported that thymectomy prolongs the tolerance to bovine γ-globulin (BGG) induced in the adult mouse8. The purpose of these experiments was to investigate the effect of whole-body X-radiation on the termination of tolerance in thymectomized and sham-operated mice.

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Authors and Affiliations

  1. Department of Medicine, University of Colorado Medical Center, Denver, Colorado

    HENRY N. CLAMAN & WENDY McDONALD

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  1. HENRY N. CLAMAN
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  2. WENDY McDONALD
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CLAMAN, H., McDONALD, W. Thymus and X-radiation in the Termination of Acquired Immunological Tolerance in the Adult Mouse. Nature 202, 712–713 (1964). https://doi.org/10.1038/202712b0

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