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Stimulation of Glucose Utilization by Insulin in Human Adipose Tissue Homogenates

Abstract

To date no effect of insulin on utilization of glucose in a cell-free preparation has been described. Indeed, the apparent ineffectiveness of insulin in cell-free preparations was a major clue to the discovery of the insulin stimulation of trans-membrane transport. We have been examining utilization of glucose in human adipose tissue and have observed a distinct stimulation of utilization of glucose by insulin added to homogenates of omentum.

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KAHLENBERG, A., KALANT, N. Stimulation of Glucose Utilization by Insulin in Human Adipose Tissue Homogenates. Nature 203, 83 (1964). https://doi.org/10.1038/203083b0

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