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Rejection of Isogeneic Murine Skin Grafts following Exposure to Allogeneic Ribonucleic Acid

Nature volume 203, pages 196–198 (1964)Cite this article

Abstract

TISSUE grafted between non-identical individuals in ordinary circumstances is recognized as foreign and rejected by the host. This rejection is an immunological phenomenon which is determined by multiple dominant histocompatibility genes. The genes are ultimately-responsible for the synthesis of lipoprotein histocompatibility antigens1. This probably occurs by means of a mechanism which transcribes coded information to messenger ribonucleic acid (RNA), and the subsequent translation of this information determines the specific proteins2.

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Author information

Author notes

  1. RONALD D. GUTTMANN

    Present address: II and IV (Harvard) Medical Services, Boston City Hospital, Boston, Massachusetts

Authors and Affiliations

  1. Tissue Bank Department, U.S. Naval Medical School, National Naval Medical Center, Bethesda, Maryland, 20014

    RONALD D. GUTTMANN, EDWARD D. KRAUS & MICHAEL F. DOLAN

Authors
  1. RONALD D. GUTTMANN
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  2. EDWARD D. KRAUS
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  3. MICHAEL F. DOLAN
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GUTTMANN, R., KRAUS, E. & DOLAN, M. Rejection of Isogeneic Murine Skin Grafts following Exposure to Allogeneic Ribonucleic Acid. Nature 203, 196–198 (1964). https://doi.org/10.1038/203196a0

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