Abstract
In the course of investigating the effects of aspirin on pregnancy in the rabbit and rat, we have observed a difference in the free salicylate blood concentrations in pregnant and non-pregnant animals. Such a difference has been reported previously by Hartiala et al.1 following oral administration of salicylamide to rabbits. Their work showed that concentrations of free salicylamide in the portal blood were much lower in pregnant than in non-pregnant animals, and that there were also small differences in the concentrations of the glucuronide conjugate of salicylamide.
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References
Hartiala, K., Pulkkinen, M., and Rauramo, L., Nature, 196, 678 (1963).
Trinder, P., Biochem. J., 57, 301 (1954).
Booth, J., and Gillette, J. R., J. Pharmacol., 137, 374 (1963).
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LESSEL, B., CLIFFE, E. Blood Salicylate during Pregnancy. Nature 203, 304–305 (1964). https://doi.org/10.1038/203304a0
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DOI: https://doi.org/10.1038/203304a0
