Abstract
IODOACETIC acid (or its derivative iodoacetamide) is known to enhance the lethal effect of ionizing radiation on mammals1–3, mammalian cells in tissue culture4, and bacteria5,6; but there are no reports of enhancement of damage which may unambiguously be called genetic. N-ethylmaleimide, on the other hand, enhances both the lethal and mutagenic effects of radiation on bacteria7–9, but has not been reported to affect higher organisms. Indeed, it was shown to be quite ineffective in enhancing radiation damage to red blood corpuscles in contrast to iodoacetic acid10.
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PURDOM, C., BRIDGES, B. Effect of Sulphydryl Reagents on the Frequency of X-ray-induced Autosomal Recessive Lethal Mutations in Drosophila melanogaster. Nature 203, 419 (1964). https://doi.org/10.1038/203419a0
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DOI: https://doi.org/10.1038/203419a0
