Abstract
THE presence of C-6 oxygenated steroids in neonatal urine was first reported by Ulstrom et al.1. It has been demonstrated2,3 that placental tissue incubated under standard conditions, is able to oxygenate at the C-6 position, while the work of Frantz et al.4 has indicated that during pregnancy the urinary concentrations of the polar steroid 6β-hydroxycortisol is elevated above the normal non-pregnant state. It appeared likely, therefore, that similar polar steroids might be present in liquor amnii.
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References
Ulstrom, R. A., Colle, E., Burley, J., and Gunville, R., J. Clin. Endocrin. Metab., 20, 1080 (1960).
Berliner, D. L., and Salhanick, H. A., J. Clin. Endocrin. Metab., 16, 903 (1956).
Lipman, M. M., Katz, F. H., and Jailer, J. W., J. Clin. Endocrin. Metab., 22, 268 (1962).
Frantz, A. G., Katz, F. H., and Jailer, J., Proc. Soc. Exp. Biol. Med., 105, 41 (1960).
Lambert, M. L., and Pennington, G. W., Nature, 197, 391 (1963).
Dixon, P. (personal communication).
Henning, H. D., and Zander, J., Hoppe-Seyler's Z. physiol. Chem., 330, 31 (1962).
Norymberski, J. K., and Woods, G. F., J. Chem. Soc., 2, 3426 (1955).
Bush, I. E., and Mahesh, V. B., Biochem. J., 17, 705 (1959).
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LAMBERT, M., PENNINGTON, G. Isolation and Identification of the 20β-Hydroxy Derivatives of 6β-Hydroxycortisol and 6β-Hydroxycortisone in Liquor Amnii. Nature 203, 656 (1964). https://doi.org/10.1038/203656a0
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DOI: https://doi.org/10.1038/203656a0
