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Genetics of Plasmids in Salmonella typhimurium

Nature volume 204, pages 1112–1113 (1964)Cite this article

Abstract

IN bacteria certain genetic determinants which may be gained or lost can multiply without incorporation in the bacterial chromosome. Some such plasmids1, the class of episomes2, may become reversibly integrated into the chromosome; for others, including the transmissible drug-resistance (R) factors3, integration has not been unequivocally demonstrated. We report observations on the transmission of an R factor and of colicine factors by conjugation and transduction in Salmonella typhimurium, and show that R factor genetic material may become attached to the bacterial chromosome—but only by becoming associated with an episome, prophage P22.

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Author notes

  1. EUGENIE DUBNAU

    Present address: Department of Microbiology, New York University School of Medicine, 550 First Avenue, New York, 16

Authors and Affiliations

  1. Guinness–Lister Research Unit, Lister Institute of Preventive Medicine, London, S.W.1

    EUGENIE DUBNAU & B. A. D. STOCKER

Authors
  1. EUGENIE DUBNAU
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  2. B. A. D. STOCKER
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DUBNAU, E., STOCKER, B. Genetics of Plasmids in Salmonella typhimurium. Nature 204, 1112–1113 (1964). https://doi.org/10.1038/2041112a0

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