Abstract
THE level of utilizable glucose represents a control of the release of free fatty acids (FFA) and, therefore, of the level of serum FFA1. Drugs acting on glucose utilization are therefore likely to be effective in changing the level of FFA. The observation that salicylate increases oxidative reactions2,3 led us to the finding that this drug is a powerful inhibitor of FFA release. Previous investigations carried out in man were contradictory. While Carlson4,5 found a decrease of plasma FFA in normal and diabetic subjects, Gilgore et al.6 did not confirm these results. However, it is likely that in the latter data there was an interference of salicylate in the determinations of FFA carried out according to Dole's method.
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References
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BIZZI, A., CODEGONI, A. & GARATTINI, S. Salicylate, a Powerful Inhibitor of Free Fatty Acid Release. Nature 204, 1205 (1964). https://doi.org/10.1038/2041205a0
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DOI: https://doi.org/10.1038/2041205a0
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