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Inhibition of Phenylquinone-induced Writhing by Narcotic Antagonists

Abstract

SINCE nalorphine was demonstrated to have potent analgesic properties1,2 and to be non-addicting in man3, a considerable effort has been directed towards finding narcotic antagonists with similar activities, but without the undesirable psychotomimetic effects produced by nalorphine4. This effort has been complicated by the fact that nalorphine not only is inactive in most analgesic tests in animals, but also will antagonize the analgesic activity of most narcotic drugs5. Only the rat flinch-jump test of Evans6 has been reported capable of detecting the analgesic activity of nalorphine. This finding, however, has yet to be reported by other workers.

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TABER, R., GREENHOUSE, D. & IRWIN, S. Inhibition of Phenylquinone-induced Writhing by Narcotic Antagonists. Nature 204, 189–190 (1964). https://doi.org/10.1038/204189a0

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