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Synthesis and Metabolism of Halothane-1-14C

Abstract

EVIDENCE that the volatile anæsthetics are not biologically inert has been developed recently in reports from this laboratory. We have measured the extent of production of carbon dioxida from 14C-diethyl ether, 14C-chloroform and 14C-methoxyflurane (14CH3OCF2CCl2H)1. Carbon-14-labelled halothane (CF3CBrClH) has not been available to us until recently when it was prepared by one of us (E. R. L.).

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References

  1. Van Dyke, R. A., Chenoweth, M. B., and Van Poznak, A., Biochem. Pharmacol. (in the press).

  2. Van Dyke, R. A., and Chenoweth, M. B., Fed. Abst., 23, 472 (1964).

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VAN DYKE, R., CHENOWETH, M. & LARSEN, E. Synthesis and Metabolism of Halothane-1-14C. Nature 204, 471–472 (1964). https://doi.org/10.1038/204471a0

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