Abstract
ANIMALS thymectomized at, or shortly after, birth show a decreased ability to develop a normal immune response. This is manifested by an impaired ability to reject homografts1–3 and heterografts1,3 and a lowering of the levels of circulating antibody to various antigens, both soluble and particulate1,3–5. This failure to develop immunological maturity possibly results from the loss of a major source of lymphoid cells, to be seeded in peripheral lymphoid organs, or the loss of the source of a humoral factor which would permit existing lymphoid tissue to participate in the immune responses5.
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References
Miller, J. F. A. P., Ann. N.Y. Acad. Sci., 99, 340 (1962).
Martinez, C., Kersey, J., Papermaster, B. W., and Good, R. A., Proc. Soc. Exp. Biol. and Med., 109, 193 (1962).
Miller, J. F. A. P., Marshall, A. H. E., and white, R. G., in Advances in Immunology, edit. by Taliaferro, W. H. and Humphrey, J. H., 2, 111 (Academic Press, New York, 1962).
Janković, B. D., Waksman, B. H., and Arnason, B. G., J. Exp. Med., 116, 159 (1962).
Archer, O., Pierce, J. C., Papermaster, B. W., and Good, R. A., Nature, 195, 347 (1962).
Thorbecke, G. J., and Benacerraf, B., in Progress in Allergy, edit. by Kallos, P., and Waksman, B. H., 6, 559 (S. Karger, New York, 1962).
Wooles, W. R., and Di Luzio, N. R., Science, 142, 1078 (1963).
Di Luzio, N. R., and Wooles, W. R., Amer. J. Physiol. (in the press).
Sohoenberg, M. D., Mumaw, V. R., Moore, R. D., and Weisberger, A. S., Science, 143, 964 (1963).
Osoba, D., and Miller, J. F. A. P., J. Exp. Med., 119, 177 (1964).
Levey, R. H., Trainin, N., and Law, L. W., J. Nat. Cancer Inst., 31, 199 (1963).
Biozzi, G., Benacerraf, B., and Halpern, B. N., Brit. J. Exp. Path., 34, 441 (1953).
Waksman, B. H., Arnason, B. G., and Jankovic, B. D., J. Exp. Med., 116, 187 (1962).
Campbell, D. H., and Garvey, J. S., Lab. Invest., 10, 1126 (1961).
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MORROW, S., DI LUZIO, N. Reticulo-endothelial Function in Thymectomized Rats. Nature 205, 193–194 (1965). https://doi.org/10.1038/205193a0
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DOI: https://doi.org/10.1038/205193a0
