Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Bronchoconstrictor Action of Bradykinin, Kallidin and Eledoisin

Nature volume 205, pages 402–403 (1965)Cite this article

Abstract

COLLIER et al.1 reported in 1959 that partially purified natural bradykinin, made by incubating trypsin with ox globulin, causes bronchoconstriction when injected into guinea-pigs. This action was confirmed for the synthetic nonapeptide2,3 as well as for the decapeptide kallidin4 and the endecapeptide eledoisin5. In contrast to the bronchoconstrictor action of serotonin and histamine, the effect of bradykinin and kallidin was completely abolished by pretreatment with acetylsalicylic acid and phenylbutazone1,4.

Access through your institution
Buy or subscribe

This is a preview of subscription content, access via your institution

Access options

Access through your institution

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Collier, H. O. J., Holgate, J. A., Schachter, M., and Shorley, P. G., J. Physiol. (Lond.), 149, 54 P (1959); Brit. J. Pharmacol., 15, 290 (1960).

    Google Scholar 

  2. Boissonas, R. A., Gottmann, St., Jaquenoud, P. A., Konzett, H., and Stürmer, E., Experientia (Basle), 16, 326 (1960).

    Article  Google Scholar 

  3. Konzett, H., and Stürmer, E., Brit. J. Pharmacol., 15, 544 (1960).

    CAS  PubMed  Google Scholar 

  4. Bhoola, K. D., Collier, H. O. J., Schachter, M., and Shorley, P. G., Brit. J. Pharmacol., 19, 190 (1962).

    CAS  PubMed  Google Scholar 

  5. Erspamer, V., and Falconieri Erspamer, G., Brit. J. Pharmacol., 19, 337 (1962).

    CAS  PubMed  Google Scholar 

  6. Konzett, H., and Rössler, R., Arch. exp. Path. und Pharmakol., 195, 71 (1940).

    Article  Google Scholar 

  7. Gjuriš, V., Heicke, B., Holtz, P., and Westermann, E., Experientia (Basle), 18, 385 (1962).

    Google Scholar 

  8. Gjuriš, V., Heicke, B., and Westermann, E., Arch. exp. Path. und Pharmakol., 247, 429 (1964).

    Article  Google Scholar 

  9. Gjuriš, V., Heicke, B., and Westermann, E., Arch. exp. Path. und Pharmakol., 248, 540 (1964).

    Article  Google Scholar 

  10. Koller, E., Helv. physiol. pharmacol. Acta, 20, 97 (1962).

    CAS  PubMed  Google Scholar 

  11. Miller, W. S., Amer. Rev. Tuberc., 5, 689 (1921).

    Google Scholar 

  12. Herxheimer, H., and Stresemann, E., J. Physiol. (Lond.), 158, 38 P (1961).

    Google Scholar 

  13. Moog, E., and Greeff, K., Arch. exp. Path. und Pharmakol., 246, 16 (1963).

    CAS  Google Scholar 

  14. Klupp, H., and Konzett, H., Arch. exp. Path. und Pharmakol., 246, 19. (1963).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Pharmacological Institute, University of Frankfurt-am-Main, Germany

    V. GJURIS̆ & E. WESTERMANN

Authors
  1. V. GJURIS̆
    View author publications

    Search author on:PubMed Google Scholar

  2. E. WESTERMANN
    View author publications

    Search author on:PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

GJURIS̆, V., WESTERMANN, E. Bronchoconstrictor Action of Bradykinin, Kallidin and Eledoisin. Nature 205, 402–403 (1965). https://doi.org/10.1038/205402a0

Download citation

  • Published:

  • Issue date:

  • DOI: https://doi.org/10.1038/205402a0

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing