Abstract
THE fact that transformation of hamster cells by ‘SV40’ results in the synthesis of new viral-induced antigen(s) was first inferred by in vivo immunity tests1–4. This phenomenon was later detected in vitro by complement-fixation5 and by immunofluorescence6,7. This latter approach has characterized the antigen as being particulate, intranuclear and present in 100 per cent of the transformed cells. Corresponding information regarding the intracellular site of the complement-fixing antigen and the proportion of cells in a culture synthesizing it has not yet been reported, and, indeed, such data are difficult to obtain by a direct approach.
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KITAHARA, T., BUTEL, J., RAPP, F. et al. Correlation between Complement-fixing Cell Antibody and Immunofluorescent Nuclear Antibody in Hamsters bearing ‘SV40’-induced Tumours. Nature 205, 717 (1965). https://doi.org/10.1038/205717a0
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DOI: https://doi.org/10.1038/205717a0
