Abstract
PREVIOUS studies from this laboratory1,2 have indicated a deficiency of Na+ ion absorption from the gastrointestinal tract in cholera1, and an inhibition of Na+ transport in the short-circuited frog skin in the presence of cholera stool. We are studying animal models to elucidate intestinal mucosal cell function in cholera. A difference in function has been noted when Na+ ion transfer in the everted intestinal sac in vitro was compared with data from loops of the adult rabbit in vivo.
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References
Phillips, R. A., Blackwell, R. Q., Wallace, C. K., and Huber, G. S., Fed. Proc., 22 (1963).
Huber, G. S., and Phillips, R. A., SEATO Conference on Cholera, Dacca, East Pakistan, 37 (National Institutes of Health, 1962).
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LOVE, A., MITCHELL, T. & NEPTUNE, E. Transport of Sodium and Water by Rabbit Ileum, in vitro and in vivo. Nature 206, 1158 (1965). https://doi.org/10.1038/2061158a0
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DOI: https://doi.org/10.1038/2061158a0
