Abstract
PHOSPHOLIPIDS are primary structural materials of the mitochondrial membrane, and numerous observations implicate them in the function of cytochrome c (ref. 1). Thus, when bound in the mitochondrial membrane, cytochrome c is not easily extractable and permits higher rates of electron transport than does added cytochrome c (refs. 2–4). Moreover, when the beef heart mitochondrial electron transport particle is treated with phospholipase, cytochrome c is released from the binding site as the soluble protein5. In addition, phospholipids are required for activity of purified preparations of reduced cytochrome c oxidase6–8, and for reactivation of succinoxidase activity after solvent extraction of mitochondria9.
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References
Ball, E. G., and Joel, C. D., Intern. Rev. Cytology, 13, 99 (1962).
Tsou, C. L., Biochem. J., 50, 493 (1952).
Slater, E. C., Biochem. J., 46, 499 (1950).
Ball, E. G., and Cooper, O., J. Biol. Chem., 266, 755 (1957).
Ambe, K. S., and Crane, F. L., Science, 129, 98 (1959).
Reich, M., and Wanio, W. W., J. Biol. Chem., 236, 3067 (1961).
Wharton, D. C., and Griffiths, D. E., Arch. Biochem. Biophys., 96, 103 (1962).
Green, D. E., and Fleischer, S., Biochim. Biophys. Acta, 70, 554 (1963).
Crane, F. L., Biochemistry, 1, 510 (1962).
Reich, M., and Wanio, W. W., J. Biol. Chem., 236, 3058 (1961).
Das, M. L., and Crane, F. L., Biochemistry, 3, 696 (1964).
Blout, E., in Optical Rotatory Dispersion, edit. by Djerassi, C., 238 (McGraw-Hill, New York, 1960).
Urnes, P., and Doty, P., in Advances in Protein Chemistry, edit. by Anfinsen, jun., C. B., Bailey, K., Anson, M. L., and Edsall, J. T., 16, 401 (Academic Press, New York, 1961).
Schellman, J. A., and Schellman, C., The Proteins, edit. by Neurath, H., 2, 1 (Academic Press, New York, 1964).
Ulmer, D. D., and Vallee, B. L., Biochemistry, 2, 1335 (1963).
Ulmer, D. D., and Vallee, B. L., in Advances in Enzymology, edit. by Nord, F. F., 27, 37 (Interscience, New York, in the press).
Gray, G. M., and Macfarlane, M. G., Biochem. J., 70, 409 (1958).
Ulmer, D. D., Biochemistry (in the press).
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ULMER, D., VALLEE, B., GORCHEIN, A. et al. Optical Rotatory Dispersion of Cytochrome c Phospholipid Complexes. Nature 206, 825–826 (1965). https://doi.org/10.1038/206825b0
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DOI: https://doi.org/10.1038/206825b0
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