Abstract
ADMINISTRATION of mannoheptulose to fasted rats causes hyperglycaemia1. This is due to a decreased supply of insulin as well as an increase in gluconeogenesis2. The insulin lack persists as long as mannoheptulose remains in the body. Thus the transient diabetes of the intact rat can be greatly prolonged by nephrectomy to prevent excretion of mannoheptulose3.
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References
Simon, E., and Kraicer, P. F., Arch. Biochem. Biophys., 69, 592 (1957).
Simon, E., Kraicer, P. F., and Shelesnyak, M. C., Endocrinol., 71, 83 (1962).
Kraicer, P. F., and Simon, E., Acta Endocrinol., 47, 517 (1964).
Simon, E., and Kraicer, P. F., presented at the Fifth Congr. Intern. Diabetes Federation, Toronto, July 20–24, 1964. Coore, H. G., and Randle, P. J., Biochem. J., 93, 66 (1964).
Coore, H. G., Randle, P. J., Simon, E., Kraicer, P. F., and Shelesnyak, M. C., Nature, 197, 1264 (1963).
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SIMON, E., KRAICER, P. Effect of Pretreatment of Rats with Mannoheptulose on the Glucose Tolerance. Nature 206, 942–943 (1965). https://doi.org/10.1038/206942a0
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DOI: https://doi.org/10.1038/206942a0
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