Abstract
MICRORADIOGRAPHIC examination of compact bone from patients with vitamin D-resistant rickets has revealed that, in addition to the presence of wide osteoid borders, there is a lack of mineral around osteocyte lacunae and their canaliculi1,2. Histological examination of decalcified material hitherto has failed to demonstrate any abnormality in the organic matrix at these sites, suggesting the presence of mineral deficiency only2. We have obtained evidence for a lesion of the bone matrix, however, by applying the following modification of Schmorl's method3.
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References
Engfeldt, B., Zetterström, R., and Winberg, J., J. Bone and Joint Surg., 38A, 1323 (1956).
Jowsey, J., in Bone Biodynamics, edit. by Frost, H. M. (Little, Brown and Co., 1964).
For Schmorl's method see Staining Procedures, edit. by Conn, H. J., et al. (The Williams and Wilkins Co., 1960).
Frost, H. M., Bosworth, D. M., Halliburton, R. H., and Sezgin, Z., Henry Ford Hosp. Med. Bull., 9, 404 (1961).
van Duyn, P., J. Histochem. Cytochem., 9, 234 (1961).
Jowsey, J., Riggs, P. L., and Kelly, P. J., Mayo Clinic Proc., 39, 480 (1964).
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STEENDIJK, R., VAN DEN HOOFF, A., NIELSEN, H. et al. Lesion of the Bone Matrix in Vitamin D-resistant Rickets. Nature 207, 426–427 (1965). https://doi.org/10.1038/207426a0
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DOI: https://doi.org/10.1038/207426a0
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