Abstract
AN abnormal marker chromosome in chronic granulo-cytic leukaemia was described by No well and Hunger ford1,2 and its occurrence widely confirmed3–7. This marker, the Philadelphia chromosome (Ph1), occurs in almost all typical cases of chronic granulocytic leukaemia and appears to be an acquired abnormality specific for the disease. The Ph1 is derived from a chromosome of pair 21 by loss of a variable proportion of the long arms.
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SPIERS, A., BAIKIE, A. Chronic Granulocytic Leukaemia: Demonstration of the Philadelphia Chromosome in Cultures of Spleen Cells. Nature 208, 497 (1965). https://doi.org/10.1038/208497a0
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DOI: https://doi.org/10.1038/208497a0
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