Primary Tissue Phase of Plasmodium berghei in Different Experimental Hosts

Abstract

IN a previous communication¹, we reported the finding of pre-erythrocytic tissue schizonts of P. berghei in the liver of an experimentally infected young hamster. The forms observed were few in number, involving examination of many hundreds of stained liver sections. The sporozoites used in the former experiments were derived from experimentally infected Anopheles quadrimaculatus. In this laboratory vector only small numbers of viable sporozoites reached the salivary glands. The introduction of Anopheles stephensi as an experimental vector of P. berghei² has greatly facilitated and advanced our work, for in this mosquito species invasion of the salivary glands by very large numbers of sporozoites takes place with regularity after exposure to gametocyte carriers and maintenance at 21° C.