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Possible Neurotoxicity of Diisopropyl Phosphorofluoridate in Guinea-pigs

Nature volume 209, page 1032 (1966)Cite this article

Abstract

NEUROTOXICITY (demyelination and axon degeneration) caused by various organophosphorus compounds is said to occur only in certain species1,2. According to Davies1, guinea-pigs show no delayed paralytic effect after treatment with one of the neurotoxic compounds. We have found that guineapigs treated with diisopropyl phosphorofluoridate (DFP) show delayed paralytic effects. This report outlines the gross signs of neurological damage observed.

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References

  1. Davies, D. R., Handbuch Exp. Pharmakol., 863 (Springer-Verlag, Berlin, 1963).

  2. Heath, D. F., in Physiological Sciences, 13, 332 (Pergamon Press, London and New York, 1961).

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Authors and Affiliations

  1. Physiology Section, Defence Research Board of Canada, Suffield Experimental Station, Ralston, Alberta

    G. S. FUKUYAMA & D. W. GOLDIE

Authors
  1. G. S. FUKUYAMA
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  2. D. W. GOLDIE
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FUKUYAMA, G., GOLDIE, D. Possible Neurotoxicity of Diisopropyl Phosphorofluoridate in Guinea-pigs. Nature 209, 1032 (1966). https://doi.org/10.1038/2091032a0

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