Abstract
CHANGES in the level of glycoproteins have been reported for a large number of conditions, primarily in man1–6. Since glycoproteins contain a number of sugar components for which quantitative methods are available, many of these methods have been used to estimate the serum- or plasma-bound carbohydrate. With the refinements of the thiobarbituric method7 for a semi-specific assay of N-acetyl neuraminic acid, we have made use of this method to investigate the changes with age in the concentration of plasma-bound sialic acid in the rat in an initial effort to use experimental animals in the investigation of the physiological significance of glycoproteins.
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DAIL, D., RICHMOND, J. Effect of Age on Serum-bound Sialic Acid in Rats. Nature 209, 303 (1966). https://doi.org/10.1038/209303a0
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DOI: https://doi.org/10.1038/209303a0
