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Effect of Antigen on the Structural Configuration of Homologous Antibody following Antigen-Antibody Combination

Nature volume 210, pages 1071–1072 (1966)Cite this article

Abstract

THE exposure of new antigenic determinant groups in rabbit antibody following combination with homologous BSA antigen has been reported1. The structural alterations occurring in the rabbit antibody molecule as a result of such combination are similar to those which Ishizaka has shown to be responsible for irritative skin reactions of soluble antigen-antibody complexes in guineapigs2. Nevertheless, in the case of the low molecular weight antigens already investigated (for example, BSA and ovalbumin), only certain ratios of antigen to antibody—three molecules of antigen to two of antibody, for example—are effective in the induction of such alterations in the antibody molecule.

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References

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Authors and Affiliations

  1. Department of Experimental Pathology, University of Birmingham,

    C. S. HENNEY & D. R. STANWORTH

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  1. C. S. HENNEY
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  2. D. R. STANWORTH
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HENNEY, C., STANWORTH, D. Effect of Antigen on the Structural Configuration of Homologous Antibody following Antigen-Antibody Combination. Nature 210, 1071–1072 (1966). https://doi.org/10.1038/2101071a0

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