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Urea Cycle Enzyme Activities of Liver of the African Lion
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  • Letter
  • Published: 01 June 1966

Urea Cycle Enzyme Activities of Liver of the African Lion

  • G. W. BROWN jun.1 

Nature volume 210, page 1367 (1966)Cite this article

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  • 1 Citations

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Abstract

IN the course of a continuous survey1,2 on the occurrence and levels of activity of ornithine–urea cycle3 enzymes, an unexpected opportunity was afforded for quantitative measurement of these activities in the instance of the African lion, Felis leo. At the Vilas Park Zoo in Madison (Wisconsin) the director, Mr. Dan Watson, decided that an infirm male lion about twelve years old had to be destroyed. The lion exhibited progressive difficulty in its ability to leap to a platform some 2 m high in the cage; this created a feeding problem and difficulty in moving the animal to an outside exercise yard.

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References

  1. Brown, jun., G. W., and Cohen, P. P., Biochem. J., 75, 82 (1960).

    Article  CAS  Google Scholar 

  2. Cohen, P. P., and Brown, jun., G. W., in Comparative Biochemistry, edit. by Florkin, M., and Mason, H. S., 2, 161 (Academic Press, New York, 1960).

    Book  Google Scholar 

  3. Krebs, H. A., and Henseleit, K., Z. Physiol. Chem., 210, 33 (1932).

    Article  CAS  Google Scholar 

  4. Brown, jun. G. W., and Cohen, P. P., J. Biol. Chem., 234, 1769 (1959).

    CAS  PubMed  Google Scholar 

  5. Ratner, S., in Methods in Enzymology, edit. by Colowick, S. P., and Kaplan, N. O., 2, 356 (Academic Press, New York, 1955).

    Book  Google Scholar 

  6. Clementi, A., Arch. Fisiol., 13, 189 (1915).

    Google Scholar 

  7. Fuchs, B., Z. Physiol. Chem., 114, 101 (1921).

    Article  CAS  Google Scholar 

  8. Iseki, T., and Imamura, H., Z. Physiol. Chem., 270, 28 (1941).

    Article  CAS  Google Scholar 

  9. Greenstein, J. P., Jenrette, W. V., Mider, G. B., and White, J., J. Nat. Cancer Inst., 1, 687 (1940–41).

    Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Biochemistry and Nutrition, University of Texas Medical Branch, Galveston, Texas

    G. W. BROWN jun.

Authors
  1. G. W. BROWN jun.
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BROWN, G. Urea Cycle Enzyme Activities of Liver of the African Lion. Nature 210, 1367 (1966). https://doi.org/10.1038/2101367a0

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  • Published: 01 June 1966

  • Issue date: 25 June 1966

  • DOI: https://doi.org/10.1038/2101367a0

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