Abstract
WHILE investigating the effect of acetylsalicylic acid (aspirin) on complement (C′) activity, it was observed that incorporation of 40 mg per cent of the drug in a well-buffered reagent diluent, 0.15 M triethanolamine buffered salt (TBS) solution1, significantly increased the haemolytic activity of human complement (HuC′)2. Since it was also noted that the drug slightly reduced the pH of the reaction mixture, the studies were extended to investigate the effect of pH. change on HuC′ activity.
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References
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FOGEL, B., HOOK, W. & FIFE, E. Effect of pH on Human Complement Activity. Nature 210, 1381 (1966). https://doi.org/10.1038/2101381a0
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DOI: https://doi.org/10.1038/2101381a0
