Abstract
IT has been demonstrated by Firemark, Barlow and Roth1 that the concentration of pralidoxime (PAM) in the rat brain cortex after a single intravenous injection of PAM-14C is significantly higher than in other brain regions. The present communication reports an attempt to see whether such a relatively small dose of PAM as used by these authors (20 mg/kg) is able to reactivate satisfactorily the phosphorylated cholinesterase in the brain cortex of rats poisoned with lethal doses of paraoxon.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Firemark, H., Barlow, C. F., and Roth, L. J., J. Pharmacol., 145, 252 (1964).
Cholinesterases and Anticholinesterase Agents, edit. by Koelle, G. B., 955 and 981 (Springer-Verlag, Berlin, 1963).
Fleisher, J. H., Corrigan, J. P., and Howard, J. W., Brit. J. Pharmacol., 13, 291 (1958).
Longo, V. G., Nachmansohn, D., and Bovet, D., Arch. Intern. Pharmacodyn., 123, 282 (1958).
Wislicki, L., Arch. Intern. Pharmacodyn., 129, 1 (1960).
Namba, T., and Hiraki, K., J. Amer. Med. Assoc., 166, 1834 (1958).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
MILOŠEVIĆ, M., ANDJELKOVIĆ, D. Reactivation of Paraoxon-inactivated Cholinesterase in the Rat Cerebral Cortex by Pralidoxime Chloride. Nature 210, 206 (1966). https://doi.org/10.1038/210206a0
Issue date:
DOI: https://doi.org/10.1038/210206a0
This article is cited by
-
Brain neuronal RNA metabolism during acute soman toxication: Effects of antidotal pretreatments
Neurochemical Research (1983)
