Abstract
WITH the recent development of potent penicillinase-resistant semi-synthetic cephalosporins1, there is considerable interest in the parent antibiotic, cephalosporin C (ref. 2). This antibiotic, which displays a peak of ultra-violet absorption at 260 mµ, is often detected on paper chromatograms by exposure to a source of ultraviolet light. Using this technique during somo investigations on the biosynthesis of the antibiotic3, I noted an extreme lability of cephalosporin C to ultra-violet light.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Godzeski, C. W., Brier, G., and Pavey, D. E., App. Microbiol., 11, 122 (1963). Jago, M., Brit. J. Pharmacol., 22 22 (1964). Muggleton, P. W., O'Callaghan, C. H., and Stevens, W. K., Brit. Med. J., ii, 1234 (1964). Frost, B. M., and Valiant, M. E., J. Path. Bact., 88, 125 (1964).
Abraham, E. P., Pharmacol. Reviews, 14, 473 (1962).
Demain, A. L., Trans. N.Y. Acad. Sci., Ser. II, 25, 731 (1963).
Batchelor, F. R., Doyle, F. P., Naylor, J. H. C., and Rolinson, G. N., Nature, 183, 257 (1959).
Jeffery, J. D'a, Abraham, E. P., and Newton, G. G. F., Biochem. J., 81, 591 (1961).
Abraham, E. P., and Newton, G. G. F., Biochem. J., 79, 377 (1961).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
DEMAIN, A. Destruction of Cephalosporin C by Ultraviolet Light. Nature 210, 426–427 (1966). https://doi.org/10.1038/210426b0
Issue date:
DOI: https://doi.org/10.1038/210426b0
