Abstract
FOR several years we have been engaged at these laboratories in an investigation of the physical, chemical, and pharmacological properties of various mesoionic heterocyclic ring systems. In the first of these systems investigated—the sydnones (I)—we found marked central nervous system stimulation1–6. 
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References
Kier, L. B., Fox, L. E., Dhawan, D., and Waters, I. W., Nature, 195, 817 (1962).
Kier, L. B., and Dhawan, D., J. Pharm. Sci., 51, 1058 (1962).
Dhawan, D., and Kier, L. B., J. Pharm. Sci., 53, 83 (1964).
Fregly, M. J., Kier, L. B., and Dhawan, D., Toxicol. and App. Pharmacol., 6, 529 (1964).
Kier, L. B., Dhawan, D., and Fregly, M. J., J. Pharm. Sci., 53, 677 (1964).
Lawson, K. D., Brey, W. S., and Kier, L. B., J. Amer. Chem. Soc., 86, 463 (1964).
Kier, L. B., Dodd, M. C., Sapko, P., and Stewart, T. G., Nature, 204, 697 (1964).
Stewart, T. G., and Kier, L. B., J. Pharm. Sci., 54, 731 (1965).
Ponzio, G., Gazz. Chim. Ital., 63, 471 (1933).
Boyer, J. H., and Canter, F. C., J. Amer. Chem. Soc., 77, 1280 (1955).
Boyer, J. H., and Hernandez, J. A., J. Amer. Chem. Soc., 78, 5124 (1956).
Hashimoto, M., and Ohta, M., Bull. Chem. Soc. Japan, 35, 766 (1962).
Farrar, W. V., J. Chem. Soc., 906 (1964).
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KIER, L., AL-SHAMMA, A., CAMPBELL, D. et al. A New Class of Hypotensive Agents. Nature 210, 742 (1966). https://doi.org/10.1038/210742a0
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DOI: https://doi.org/10.1038/210742a0
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