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A γ-Globulin Genetic Factor related to Gm(a) but localized to a Different Portion of the same Heavy Chains

Nature volume 210, page 866 (1966)Cite this article

Abstract

PREVIOUS investigations have indicated that Gm(a)* and Gm(f)* are genetic characters localized in various areas of the major heavy chain class1–3 of human γG globulins. These determinants, detected as antigens, segregate in most populations, as if controlled by allelic genes, and occur independently in myeloma proteins from Caucasians. A previous report indicated that specific reagents for the human genetic factors can be produced by immunizing rabbits with myeloma proteins4. In order to analyse in a more satisfactory way the genetic control of different portions of the heavy chains, it seemed desirable deliberately to immunize with critical protein fragments in order to disclose additional genetic sites believed to be present but not detected by available antisera.

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Authors and Affiliations

  1. Rockefeller University, New York City

    STEPHEN D. LITWIN & HENRY G. KUNKEL

Authors
  1. STEPHEN D. LITWIN
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  2. HENRY G. KUNKEL
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LITWIN, S., KUNKEL, H. A γ-Globulin Genetic Factor related to Gm(a) but localized to a Different Portion of the same Heavy Chains. Nature 210, 866 (1966). https://doi.org/10.1038/210866a0

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