Abstract
DIPICOLINIC acid (DPA, pyridine-2,6-dicarboxylic acid) is synthesized during sporogenesis in spore-forming bacteria and excreted during germination as the calcium salt. Heat resistance of spores has long been thought to be associated with the presence of DPA. Church and Halvorson1 reported a quantitative relationship between heat resistance and DPA content in spores. Black et al.2 found that at a concentration of DPA greater than 50 µg/mg dry spores the heat susceptibility appears to remain constant and minimal.
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References
Church, B. D., and Halvorson, H., Nature, 183, 124 (1959).
Black, S. H., Hashimoto, T., and Gerhardt, P., Canad. J. Microbiol., 6, 213 (1960).
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MISHIRO, Y., OCHI, M. Effect of Dipicolinate on the Heat Denaturation of Proteins. Nature 211, 1190 (1966). https://doi.org/10.1038/2111190a0
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DOI: https://doi.org/10.1038/2111190a0
