Abstract
RECENTLY I reported1 lysis of thrombi in the veins and arteries of animals with sodium gluconate and a dialysable constituent of fibrin extract or whole blood. The ultraviolet absorption spectrum of fibrin extract displayed a maximum at 275 mµ and a minimum at 247 mµ. These values happen to coincide closely with those recorded for tyrosine. This finding suggested that L-tyrosine might be successfully substituted for fibrin extract and, if this was so, that a peptide formed from the amino-acid and gluconic acid would also be fibrinolytic.
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References
Kopper, P. H., Nature, 211, 43 (1966).
Iacobellis, M., Arch. Biochem. Biophys., 59, 199 (1955).
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KOPPER, P. Rapid Induction of in vivo Fibrinolysis with D-Gluconyl-L-tyrosine. Nature 211, 1417 (1966). https://doi.org/10.1038/2111417a0
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DOI: https://doi.org/10.1038/2111417a0
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