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Biological Activity of Phosphoramidothionates

Abstract

IN the course of our work on this class of compound an animal-anthelmintic1 and a selective herbicide2 had previously been discovered. Common to the structures of the two compounds was the linking of the phosphor-amidothionate group (I) to a chlorinated phenyl ring by an oxygen atom. Our speculations on biological activity led us to replace this atom by nitrogen and to investigate the effects of a different type of toxophoric phosphor-amidothionate group (II).

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References

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TOLKMITH, H. Biological Activity of Phosphoramidothionates. Nature 211, 522–523 (1966). https://doi.org/10.1038/211522a0

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