Abstract
IN the early stages of collagen fibrogenesis, soluble forms of collagen can be extracted with salt solutions; as the tissue develops, dilute acids and acidic buffers are needed. Eventually these reagents also become ineffective as a relatively insoluble form of collagen is elaborated. This transformation or “maturing” is believed to be caused by an increase in the number of intramolecular and intermolecular cross-links1.
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References
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CARMICHAEL, D. Electrophoretic Fractionation of Heat-denatured Eucollagen. Nature 211, 861–862 (1966). https://doi.org/10.1038/211861a0
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DOI: https://doi.org/10.1038/211861a0
