Lactate Dehydrogenase Isoenzymes in Developing Human Muscle

Abstract

THERE has recently been considerable interest in the changes which occur in the lactate dehydrogenase (LDH) isoenzyme pattern of skeletal muscle when the tissue is affected by a natural or experimental lesion, particularly with reference to human muscle disease. These changes have been regarded as a failure of maturation¹, or, alternatively, as a process of de-differentiation, for similar changes have been seen in human neurogenie atrophy^2,3 and progressively after experimental denervation in animals³.