Abstract
THE mechanism of action of psychotropic drugs has been widely investigated. For a number of years, work has been focused on this problem in our laboratory. We have investigated particularly the amino-acids1–3 and phosphatases4,5 of the brain. We found that phosphatase activity in brain, measured in the physiological range of pH (7.2–7.5) with p-nitrophenolphosphate as a substrate, was markedly increased by chlorpromazine in vitro (Table 1) as well as in vivo (Table 2).
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DE WAART, C., SIETSMA, J., FERWERDA, W. et al. Action of Chlorpromazine on Non-specific Phosphatase bound to Membranes in Brain Tissue of the Rat. Nature 212, 848–849 (1966). https://doi.org/10.1038/212848b0
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DOI: https://doi.org/10.1038/212848b0
