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Glucosamine Acetoacetate Condensate: a New Anti-Alloxan-Diabetes Factor

Nature volumeΒ 213,Β pages 1254–1255 (1967)Cite this article

Abstract

β€œIT has been postulated that a gradual accumulation of ketone bodies in the system might be responsible for the onset of hyperglycemia and that the rise of blood sugar might be due not only to overproduction or nonutilization of glucose but, also, to a natural mechanism to combine with some toxic metabolites in the system.”1. It has been proposed that the condensation product of glucose and acetoacetate (furoate condensate) prevents alloxan diabetes even when the product is in very low concentration, and that this condensation product is formed in the urine of normal people and not in those of diabetic patients2. A new route of glucose utilization and ketolysis is suggested, therefore3.

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References

  1. Nath, M. C., and Sahu, U. K., Proc. Soc. Exp. Biol. and Med., 87, 287 (1954).

    ArticleΒ  CASΒ  Google ScholarΒ 

  2. Gonzalez, F. G., and Aparicio, F. G. C., An. Fis. Quim., 41, 846 (1945).

    CASΒ  Google ScholarΒ 

  3. Nath, M. C., and Sahu, U. K., J. Sci. Indust. Res., 123, 191 (1953).

    Google ScholarΒ 

  4. Gonzalez, F. G., An. Fis. y. Quim., 32, 815 (1934).

    Google ScholarΒ 

  5. Nath, M. C., and Sahu, U. K., Proc. Soc. Exp. Biol. and Med., 79, 608 (1952).

    ArticleΒ  CASΒ  Google ScholarΒ 

  6. Rimington, C., Biochem. J., 34, 931 (1940).

    ArticleΒ  CASΒ  Google ScholarΒ 

  7. Hoffman, W. S., J. Biol. Chem., 120, 51 (1937).

    CASΒ  Google ScholarΒ 

  8. Good, C. A., Kramer, H., and Somogyi, M., J. Biol. Chem., 100, 485 (1932).

    Google ScholarΒ 

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Authors and Affiliations

  1. Drury College,

    JORGE L. PADRONΒ &Β MIRIAM SULMAN

  2. Burge Protestant Hospital, Springfield, 2, Missouri

    NOEL R. LEWIS

Authors
  1. JORGE L. PADRON
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  2. MIRIAM SULMAN
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  3. NOEL R. LEWIS
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PADRON, J., SULMAN, M. & LEWIS, N. Glucosamine Acetoacetate Condensate: a New Anti-Alloxan-Diabetes Factor. Nature 213, 1254–1255 (1967). https://doi.org/10.1038/2131254a0

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