Abstract
SELENIUM, long considered an element toxic to the majority of living organisms, may be of physiological importance in various animals as an indispensable part of the diet1–5. It may replace the sulphur atom in sulphur amino-acids6–14 in the proteins of plants, animals and micro-organisms15–18, and could stimulate cell division in a filamentous mutant of Candida albicans19. This stimulation has been related to the replacement of sulphydryl groups in the composition of the cell wall with —SeH groups, the greater stability of which can overcome in the filamentous mutant the deficiency in proteiin-disulphuro-reductase20, an enzyme indispensable to plastification of the cell wall21.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Schwartz, K., and Foltz, C. M., J. Amer. Chem. Soc., 79, 3292 (1957).
Proctor, J. B., Hogue, B. L., and Warner, R. G., J. Animal Sci., 17, 1183 (1958).
Muth, O. H., Olefield, J. B., Remmert, L. F., and Schubert, J. R., Science, 128, 1090 (1958).
Patterson, E. L., Milstrey, R., and Stokstad, E. L. R., Proc. Soc. Exp. Biol. and Med., 95, 617 (1957).
Nesheim, M. C., and Scott, M. L., J. Nutrit., 65, 601 (1958).
Horn, M. J., and Jones, D. B., J. Biol. Chem., 139, 649 (1941).
Trelease, S. F., Di Somma, A. A., and Jacobs, A. L., Science, 132, 618 (1960).
Schrift, A., and Virupaksha, T. K., Biochim. Biophys. Acta, 71, 483 (1963).
Virupaksha, T. K., and Schrift, A., Biochim. Biophys. Acta, 74, 791 (1963).
Jacobs, A. L., thesis, Univ. Columbia (University Microfilms Inc., 62–5183, Ann Arbor, Michigan, 1962).
Peterson, P. J., and Buttler, G. W., Austral. J. Biol. Sci., 15, 126 (1962).
Tuve, T., and Williams, H. W., J. Biol. Chem., 236, 597 (1961).
Blau, M., Biochim. Biophys. Acta, 49, 389 (1961).
Hedegaard, J., Falcone, G., and Calabro', S., C.R. Soc. Biol., 157, 280 (1963).
Franke, K. W., and Painter, E. P., Cereal Chem., 13, 67 (1936).
Horn, M. J., Nelson, E. M., and Jones, D. B., Cereal Chem., 13, 125 (1936).
Painter, E. P., and Franke, K. W., Cereal Chem., 13, 172 (1936).
Painter, E. P., Chem. Revs., 28, 179 (1941).
Nickerson, W. J., Taber, W. A., and Falcone, G., Canad. J. Microbiol., 2, 575 (1956).
Falcone, G., and Nickerson, W. J., Giorn. Microbiol., 4, 105 (1957).
Falcone, G., and Nickerson, W. J., Science, 124, 722 (1956).
Smythe, C. V., J. Biol. Chem., 142, 343 (1942).
Smythe, C. V., and Halliday, D., J. Biol. Chem., 144, 237 (1942).
Schlossmann, K., and Lynen, F., Biochem. Z., 328, 591 (1957).
Kearney, E. B., and Singer, T. P., Biochim. Biophys. Acta, 11, 276 (1953).
Kearney, E. B., and Singer, T. P., Biochim. Biophys. Acta, 14, 570 (1954).
Chapeville, F., and Fromageot, P., Biochim. Biophys. Acta, 14, 415 (1954).
Shepherd, C. J., J. Gen. Microbiol., 15, 29 (1956).
Kassel, B., and Brand, E., J. Biol. Chem., 125, 115 (1938).
Schrift, A., Bot. Rev., 24, 550 (1958).
Trelease, S. F., and Beath, O. A., Selenium (published by authors, New York, 1949).
Hatch, F. T., Takeyama, S., and Buchanan, J. M., Fed. Proc., 18, 243(1959).
Kisliuk, R. L., and Woods, D. T., J. Gen. Microbiol., 18, XV (1958).
Helleiner, C. W., Kisliuk, R. L., and Woods, D. D., J. Gen. Microbiol., 18, XV (1958).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
FALCONE, G., GIAMBANCO, V. Synthesis of Seleno-amino-acids in Cell Free Extracts of Candida albicans. Nature 213, 396–398 (1967). https://doi.org/10.1038/213396a0
Issue date:
DOI: https://doi.org/10.1038/213396a0
This article is cited by
-
Selenium metabolism in a strain ofFusarium
Biological Trace Element Research (1988)
