Abstract
PERMIT me to bring to the notice of Professor Britton Chance and Leena Mela an obvious omission from the references to their paper1 on proton movement in mitochondrial membranes. Is it possible that they can discuss the release of hydrogen ions at interfaces, associated with redox processes, without mentioning Conway's redox pump theory2 for the active secretion of hydrogen ions by the cells of the gastric mucosa? Conway's theory, which predates other redox theories mentioned, specifically suggests electron transfer from flavoproteins to cytochromes as being particularly favourable for the active release of hydrogen ions from the cells of the gastric mucosa. He has also presented evidence3 for a similar mechanism in fermenting yeast.
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References
Chance, B., and Mela, L., Nature, 212, 372 (1966).
Conway, E. J., and Brady, T., Nature, 162, 456 (1948).
Conway, E. J., The Biochemistry of Gastric Acid Secretion (C. C. Thomas, Springfield, 1953).
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KERNAN, R. Redox Pump Theory for Active Secretion of Hydrogen Ions. Nature 213, 734 (1967). https://doi.org/10.1038/213734a0
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DOI: https://doi.org/10.1038/213734a0
