Abstract
Singh and Koppelman1,2 fit a kinetic model to data of Harris and Watts3. Their model depends on the equation 
where λ is constant. But the data insist that λ is not constant: it changes by a factor of 3.5 during the course of the experiment. Singh and Koppelman2 try to overcome the difficulty by approximating an exponential as a straight line. They do not succeed. Kinetic models based on erroneous assumptions are unacceptable. Any model which can satisfactorily fit the data of Harris and Watts must be rather more sophisticated than that of Singh and Koppelman.
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References
Singh, U. N., and Koppelman, R., Nature, 198, 181 (1963).
Singh, U. N., and Koppelman, R., Nature, 211, 75 (1966).
Harris, H., and Watts, J. W., Proc. Roy. Soc., B, 156, 109 (1962).
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GILBERT, N. Relationship between Nuclear and Cytoplasmic RNA. Nature 213, 809–810 (1967). https://doi.org/10.1038/213809b0
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DOI: https://doi.org/10.1038/213809b0
