Abstract
Creech and Jones1 showed that various proteins can be labelled with a fluorescent dye without material effect on their biological or immunological properties. Through this work it became possible to localize antigens and, by the use of the sandwich technique2, to localize antibodies.
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Creech, H. J., and Jones, R. N., J. Amer. Chem. Soc., 62, 1970 (1940).
Weller, T. H., and Coons, A. H., Proc. Soc. Exp. Biol. N.Y., 86, 789 (1954).
Taylor, H. E., Culling, C. F. A., and McDonald, T. J., Amer. J. Path., 48, 921 (1966).
Culling, C. F. A., Handbook of Histopathological Technique, second ed. (Butterworths, London).
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CULLING, C. Permanent Mounting Method for Fluorescent Antibody Preparations. Nature 214, 1140 (1967). https://doi.org/10.1038/2141140a0
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DOI: https://doi.org/10.1038/2141140a0
