Abstract
SINCE the first report of mutagenesis in Escherichia coli induced by N-methyl-N′-nitro-N-nitrosoguanidine (NG)1, this agent has been widely used as a mutagen in bacterial genetics. In suitable conditions it combines extraordinary mutagenicity with a high survival of the treated cells2. Besides being a powerful mutagen, it has also been shown to have antitumour activity3. Furthermore, Allan and McCalla4 have proved that NG induces lambda prophage development and subsequent lysis of E. coli C 600 (λ).
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References
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MALKE, H. Prophage Induction by N-Methyl-N′-nitro-N-nitrosoguanidine in a Group A Streptococcus. Nature 214, 811–812 (1967). https://doi.org/10.1038/214811a0
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DOI: https://doi.org/10.1038/214811a0
