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Site of Action of Aflatoxin on Human Liver Cells in Culture

Nature volume 214, pages 814–815 (1967)Cite this article

Abstract

THE hepatotoxic activity of a number of metabolic compounds produced by fungi, particularly the aflatoxins formed by strains of the Aspergillus flavus-oryzae group, is now fully established. The addition of aflatoxin to human diploid and heteroploid embryo lung cell cultures by Legator and Withrow1 resulted in suppression of mitosis. Legator, Zuffante and Harp2 used heteroploid embryo lung cells and found that both crude aflatoxin and aflatoxin B1 suppressed the synthesis of DNA. Zuckerman and Fulton3 demonstrated the cytotoxicity of aflatoxin B1 on human embryo liver cells in tissue culture. We now report further investigations of the site of action of aflatoxin B1 in human liver cells as well as the results of titration of three aflatoxin fractions.

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References

  1. Legator, M. S., and Withrow, A., J. Assoc. Offic. Agric. Chemists, 47, 1007 (1964).

    CAS  Google Scholar 

  2. Legator, M. S., Zuffante, S. M., and Harp, A. R., Nature, 208, 345 (1965).

    Article  ADS  CAS  Google Scholar 

  3. Zuckerman, A. J., and Fulton, F., Brit. Med. J., 2, 90 (1966).

    Article  Google Scholar 

  4. Zuckerman, A. J., Tsiquaye, K. N., and Fulton, F., Brit. J. Exp. Path., 48, 20 (1967).

    CAS  PubMed  Google Scholar 

  5. Clifford, J. I., and Rees, K. R., Nature, 209, 312 (1966).

    Article  ADS  CAS  Google Scholar 

  6. Clifford, J. I., and Rees, K. R., Biochem. J., 102, 65 (1967).

    Article  CAS  Google Scholar 

  7. Clifford, J. I., Rees, K. R., and Stevens, M. E. M., Biochem. J., 103, 285 (1967).

    Google Scholar 

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Author information

Authors and Affiliations

  1. London School of Hygiene and Tropical Medicine, London, W.C.1

    A. J. ZUCKERMAN

  2. University College Hospital Medical School, London, W.C.1

    K. R. REES

  3. Imperial Cancer Research Fund, London, W.C.2

    D. INMAN & VALERIE PETTS

Authors
  1. A. J. ZUCKERMAN
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  2. K. R. REES
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  3. D. INMAN
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  4. VALERIE PETTS
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ZUCKERMAN, A., REES, K., INMAN, D. et al. Site of Action of Aflatoxin on Human Liver Cells in Culture. Nature 214, 814–815 (1967). https://doi.org/10.1038/214814b0

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